2000 - 2004 Publications

[151] Electrical circuitry in biology: emerging principles from protein structure (2004)

Leys, D. & Scrutton, N. S.

Curr. Opin. Struct. Biol., 14, 642-647, DOI: 10.1016/j.sbi.2004.10.002

[150] Hydrogen tunneling in quinoproteins (2004)

Masgrau, L., Basran, J., Hothi, P., Sutcliffe, M. J. & Scrutton, N. S.

Archives Biochem. Biophys. 428, 41-51, DOI: 10.1016/j.abb.2004.03.013

[149] Extensive domain motion and electron transfer in the human ETF-MCAD complex (2004)

Toogood, H. S., van Thiel, A., Basran, J., Sutcliffe, M. J., Scrutton, N. S. & Leys, D.

J. Biol. Chem., 279, 32904-32912, DOI: 10.1074/jbc.M404884200 Free Access

[148] Atomic resolution structures and solution behaviour of enzyme-substrate complexes of Enterobacter cloacae pentaerythritol tetranitrate reductase: multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation (2004)

Khan, H., Barna, T., Harris, R. J., Bruce, N. C., Barsukov, I., Munro, A. W., Moody, P. C. E. & Scrutton, N. S.

J. Biol. Chem., 279, 30563 - 30572, DOI: 10.1074/jbc.M403541200 Free Access

[147] Thermodynamic and kinetic analysis of the isolated FAD-domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe-1395 (2004)

Dunford, A. J., Marshall, K. R., Munro, A. W. & Scrutton, N. S.

Eur. J. Biochem., 271, 2548-2560, DOI: 10.1111/j.1432-1033.2004.04185.x Free Access

[146] Thermodynamic basis of electron transfer in dihydoorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR and ENDOR spectroscopy (2004)

Mohsen, A. A., Rigby, S. E., Jensen, K. F., Munro, A. W. & Scrutton, N. S.

Biochemistry, 43, 6498-6510, DOI: 10.1021/bi036179i

[145] Biotransformation of explosives by the Old Yellow Enzyme family of flavoproteins (2004)

Williams, R. E., Rathbone, D. A., Scrutton, N. S. & Bruce, N. C.

Appl. Environ. Microbiol., 70, 3566-3574, DOI: 10.1128/AEM.70.6.3566-3574.2004

[144] Solution structure of the two-iron rubredoxin of Pseudomonas oleovorans determined by NMR spectroscopy and solution X-ray scattering, and interactions with rubredoxin reductase (2004)

Perry, A., Tambyrajah, W. Grossman, J. G., Lian, L-Y. & Scrutton, N. S.

Biochemistry, 43, 3167-3182, DOI: 10.1021/bi035817u

[143] Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase (2004)

Olteanu, H., Wolthers, K. R., Munro, A. W., Scrutton, N. S. & Banerjee, R.

Biochemistry, 43, 1988-1997, DOI: 10.1021/bi035910i

[142] Electron transfer in human methionine synthase reductase studied by stopped-flow spectrophotometry (2004)

Wolthers, K. R. & Scrutton, N. S.

Biochemistry, 43, 490-500, DOI: 10.1021/bi0356303

[141] Chemical aspects of amine oxidation by flavoprotein enzymes (2004)

Scrutton, N. S.

Nat. Prod. Rep., 21, 722 - 730, DOI: 10.1039/B306788M

[140] Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase-electron transferring flavoprotein complex (2004)

Leys, D., Basran, J., Talfournier, F., Chohan, K. K., Munro, A. W., Sutcliffe, M. J. & Scrutton, N. S.

Biochem. Soc. Symp. 71, 1-14

[139] Hydrogen tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase (2003)

Basran, J., Harris, R. J., Sutcliffe, M. J. & Scrutton, N. S.

J. Biol. Chem., 278, 43973-43982, DOI: 10.1074/jbc.M305983200 Free Access

[138] Electron transfer in flavocytochrome P450BM3: kinetics of flavin reduction and oxidation, the role of Cys-999 and relationships with mammalian cytochrome P450 reductase (2003)

Roitel, O., Scrutton, N. S. & Munro, A. W.

Biochemistry, 42, 10809-10821, DOI: 10.1021/bi034562h

[137] Channeling and formation of 'active' formaldehyde in dimethylglycine oxidase (2003)

Leys, D., Basran, J. & Scrutton, N. S.

EMBO Journal, 22, 4038-4048, DOI: 10.1093/emboj/cdg395 Free Access

[136] Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding: relaxation kinetic studies with coenzyme analogues (2003)

Gutierrez, A., Munro, A. W., Grunau, A., Wolf, C. R., Scrutton, N. S. & Roberts, G. C. K.

Eur. J. Biochem., 270, 2612-2621, DOI: 10.1046/j.1432-1033.2003.03633.x Free Access

[135] Cytochromes P450: novel drug targets in the war against multi drug-resistant Mycobacterium tuberculosis (2003)

Munro, A. W., McLean, K. J., Marshall, K. R., Warman, A. J., Lewis, G., Roitel, O., Sutcliffe, M. J., Kemp, C. A., Modi, N. S., Scrutton, N. S. & Leys, D.

Biochem. Soc. Trans. 31, 625-630

[134] Electron transfer in human cytochrome P450 reductase (2003)

Gutierrez, A., Grunau, A., Paine, M. J. I., Munro, A. W., Wolf, C. R., Roberts, G. C. K. & Scrutton, N. S.

Biochem. Soc. Trans. 31, 497-501

[133] Kinetic and spectroscopic characterisation of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA (2003)

McLean, K., Scrutton, N. S. & Munro, A. W.

Biochem. J. 372, 317-327, DOI: 10.1042/BJ20021692

[132] Effects of multiple ligand binding on kinetic isotope effects in PQQ-dependent methanol dehydrogenase (2003)

Hothi, P., Basran, J., Sutcliffe, M.J. & Scrutton, N. S.

Biochemistry 42, 3966-3978, DOI: 10.1021/bi027282v

[131] Molecular dissection of human methionine synthase reductase: determination of the flavin redox potentials in full-length enzyme and isolated flavin-binding domains (2003)

Wolthers, K. R., Basran, J., Munro, A. W. & Scrutton, N. S.

Biochemistry, 42, 3911-3920, DOI: 10.1021/bi027290b

[130] Extensive conformational sampling in a ternary electron transfer complex (2003)

Leys, D., Basran, J., Talfournier, F., Sutcliffe,M. J. & Scrutton, N. S.

Nature Structural Biology 10, 219-225, DOI: 10.1038/nsb894, Faculty 1000 evaluation ‘Must read’

[129] Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of human oxidoreductase NR1 (2003)

Finn, R. D., Basran, J., Roitel, O., Wolf, C. R., Munro, A. W. Paine, M. J. I. & Scrutton, N. S.

Eur. J. Biochem., 270, 1164-1175, DOI: 10.1046/j.1432-1033.2003.03474.x Free Access

[128] Electron transfer in flavocytochrome P450 BM3 and the C999A mutant: kinetics of flavin reduction and relationships with mammalian cytochrome P450 reductase. (2003)

Roitel, O., Scrutton, N. S. & Munro, A. W.

Cytochromes P450 Biochemistry, Biophysics and Drug Metabolism; Proceedings of the 13th International Conference on Cytochromes P450, Prague, Czech Republic, (Eds Anzenbacher, P. and Hudecek, J.) Monduzzi Editore, Bologna, Italy. pp. 283-285

[127] Mechanism and regulation of electron transfer in cytochrome P450 redox systems (2003)

Munro, A. W., Roitel, O., McLean, K. J., Gutierrez, A., Basran, J., Neeli, R., Paine, M. J. I., Finn, R., Wolf, C. R., Roberts, G. C. K. & Scrutton, N. S.

[126] Cytochrome P450 systems in Mycobacterium tuberculosis. (2003)

McLean, K. J., Leys, D., Marshall, K. R., Lewis, G., Warman, A. J., Scrutton, N. S. & Munro, A. W.

[125] Using trimethylamine dehydrogenase in an enzyme linked amperometric electrode: Part 2 - Rational design engineering of a 'wired' mutant (2003)

Loechel, C., Basran, A., Basran, J. Scrutton, N. S. & Hall, E. A. H.

Analyst 128, 889-898, DOI: 10.1039/B302298F

[124] Using trimethylamine dehydrogenase in an enzyme linked amperometric electrode: Part 1 - Wild-type enzyme redox mediation (2003)

Loechel, C., Basran, A., Basran, J., Scrutton, N. S. & Hall, E. A. H.

Analyst 128, 166-172, DOI: 10.1039/B211895E

[123] Relaxation kinetics of cytochrome P450 reductase (2002)

Gutierrez, A., Paine, M., Wolf, C.R., Scrutton, N.S. & Roberts, G.C.K.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 569-574

[122] Transient kinetic analysis of the reductive half reaction of methionine synthase reductase (2002)

Wolthers, K.R., Basran, J., Munro, A. W. & Scrutton, N.S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 673-678

[121] Molecular enzymology of diflavin reductases (2002)

Munro, A.W., Roitel, O., Girvan, H.M.,Lawson, R. J., Marshall, K.R., Wolthers, K., Knight, K., Basran, J., Leys, D., Scrutton, N.S., Ost, T.W.B., Miles, C.S., Chapman, S.K., Gutierrez, A. & Roberts, G.C.K.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 461-470

[120] Expression and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue: FprA (2002)

McLean, K.J., Scrutton, N. S. & Munro, A. W.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 605-610

[119] Probing the reductive reaction of the FAD and CPR domains of flavocytochrome P450 BM3 (2002)

Roitel, O., Scrutton, N. S. & Munro, A. W.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 635-640

[118] Electron transfer in the alkane hydroxylase system of Pseudomonas oleovorans (2002)

Tambyrajah, W. S., Perry, A., Lian, L.Y., Grossman, J. G. & Scrutton, N. S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 653-657

[117] Mechanistic studies of Trp-102 mutant forms of pentaerythritol tetranitrate reductase (2002)

Bruce, N. C., Harris, R. J., Khan, H., Barna, T., Moody, P. C. E. & Scrutton, N. S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 205-210

[116] Pentaerythritol tetranitrate reductase: reaction with NADPH, steroids, 2-cyclohexenone, nitroesters and nitroaromatic explosives (2002)

Bruce, N. C., Khan, H., Harris, R. J., Barna, T., Munro, P. C. E. & Scrutton, N. S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 247-252

[115] Bacterial morphinone reductase: active site structure and properties of active site mutant enzymes (2002)

Bruce, N. C., Messiha, H. L., Barna, T., Moody, P. C. E. & Scrutton, N. S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 287-292

[114] Electron transfer in the reductase domain of neuronal nitric oxide synthase (2002)

Knight, K. & Scrutton, N. S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 581-586

[113] Kinetic mechanism of dimethylglycine oxidase (2002)

Basran, A., Nietlispach, D., Meskys, R., Bhanji, N., Basran, J. & Scrutton, N. S.

Flavins and Flavoproteins; Proceedings of the Fourteenth International Symposium, St. John's College, University of Cambridge, UK (Eds. Perham, R. N., Chapman, S. K. & Scrutton, N. S.) pp. 125-130

[112] Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase (2002)

Knight, K. & Scrutton, N. S.

Biochem. J. 367, 19-30, DOI: 10.1042/BJ20020667

[111] Crystal structure of bacterial morphinone reductase and properties of the C191A mutant enzyme (2002)

Barna, T., Messiha, H. L.,Petoza, C., Bruce, N. C., Scrutton, N. S. & Moody, P. C. E.

J. Biol. Chem., 277, 30976-30983, DOI: 10.1074/jbc.M202846200 Free Access

[110] The role of histidine 42 in ascorbate peroxidase: kinetic analysis of the H42A and H42E variants (2002)

Lad, L., Mewies, M., Basran, J., Scrutton, N. S. & Raven, E. L.

Eur. J. Biochem., 269, 3182-3192, DOI: 10.1046/j.1432-1033.2002.02998.x Free Access

[109] A new conceptual framework for enzyme catalysis: hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes (2002)

Sutcliffe, M. J. & Scrutton, N. S.

Eur. J. Biochem. 269, 3096-3102, DOI: 10.1046/j.1432-1033.2002.03020.x Free Access

[108] Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters and nitroaromatic explosives (2002)

Khan, H., Harris, R. J., Barna, T., Craig, D. H., Bruce, N. C., Munro, A. W., Moody, P. C. E. and Scrutton, N. S.

J. Biol. Chem., 277, 21906-21912, DOI: 10.1074/jbc.M200637200 Free Access

[107] Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry (2002)

Basran, J.,Bhanji, N., Basran, A., Nietlispach, D., Mistry, S., Meskys, R. & Scrutton, N. S.

Biochemistry, 41, 4733-4743, DOI: 10.1021/bi025519h

[106] Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding (2002)

Gutierrez, A., Paine, M., Wolf, C. R., Scrutton, N. S. & Roberts, G. C. K.

Biochemistry, 41, 4626-4637, DOI: 10.1021/bi0159433

[105] Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein (2002)

Jones, M., Talfournier, F., Bobrov, A., Grossmann, J.G., Vekshin, N., Sutcliffe, M. J. & Scrutton, N. S.

J. Biol. Chem., 277, 8457-8465, DOI: 10.1074/jbc.M111105200 Open Access

[104] Optimising the Michaelis complex of trimethylamine dehydrogenase: identification of interactions that perturb the ionisation of substrate and facilitate catalysis with trimethylamine base (2001)

Basran, J., Sutcliffe, M. J. & Scrutton, N.S.

J. Biol. Chem., 276, 42887-42892, DOI: 10.1074/jbc.M108296200 Free Access

[103] Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N1 and C2 carbonyl region of the active site flavin (2001)

Craig, D. H., Barna, T., Moody, P. C. E., Bruce, N. C., Chapman, S. K., Munro, A. W. & Scrutton, N. S.

Biochem. J. 359 315-323

[102] Protein dynamics enhance electronic coupling in electron transfer complexes (2001)

Chohan, K. K., Jones, M., Grossman, J. G. Frerman, F., Scrutton, N. S. & Sutcliffe, M. J.

J. Biol. Chem., 276, 34142-34147, DOI: 10.1074/jbc.M101341200 Free Access

[101] QM/MM studies show substantial tunnelling for the hydrogen transfer reaction in methylamine dehydrogenase (2001)

Faulder, P.F., Tresadern, G., Chohan, K., Scrutton, N. S., Sutcliffe, M. J., Hillier, I. H. & Burton, N. A.

J. Am. Chem. Soc., 123, 8604-8605, DOI: 10.1021/ja016219a

[100] Enzymology takes a quantum leap forward (2001)

Sutcliffe, M. J. & Scrutton, N. S.

Visions of the Future: Chemistry and Life Science (Ed. Thompson, J.M.T.) Cambridge University Press. pp. 21-42.

[99] Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands (2001)

Stevenson, H., Gutierrez, A., Alderton, W.K., Lian, L-Y., & Scrutton, N.S.

Biochem. J.358 201-208.

[98] Crystal structure of pentaerythritol tetranitrate reductase: 'flipped' binding geometries for steroid substrates in different redox states of the enzyme (2001)

Barna, T., Khan, H., Bruce, N.C., Barsukov, I., Scrutton, N.S. & Moody, P.C.E.

J. Mol. Biol.,310, 433-447, DOI: 10.1006/jmbi.2001.4779

[97] Deuterium isotope effects during C-H bond cleavage by trimethylamine dehydrogenase: implications for mechanism and vibrationally assisted H-tunneling in wild-type and mutant enzymes (2001)

Basran, J., Sutcliffe, M. J. & Scrutton, N. S.

J. Biol. Chem., 276, 24581-24587, DOI: 10.1074/jbc.M101178200 Free Access

[96] αArg-237 in Methylophilus methylotrophus (sp. W3A1) electron transferring flavoprotein affords ~ 200 mV stabilization of the FAD anionic semiquinone and a kinetic block on full reduction to the dihydroquinone (2001)

Talfournier, F., Munro, A. W., Basran, J., Sutcliffe, M. J., Daff, S.,Chapman, S. K. & Scrutton, N. S.

J. Biol. Chem., 276, 20190-20196, DOI: 10.1074/jbc.M010853200 Free Access

[95] Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter sp: implications for glycine betaine catabolism (2001)

Meskys, R., Harris, R .J., Casaite, V., Basran, J. & Scrutton, N. S.

Eur. J. Biochem. 268 3390-3398, DOI: 10.1046/j.1432-1327.2001.02239.x Free Access

[94] Kinetics of CO binding and CO photodissociation in Pseudomonas stutzeri cd1-nitrite reductase: probing the role of extended N-termini in fast structural relaxation upon CO photodissociation (2001)

Wilson, E.K., Bellelli, A., Cutruzzola, F., Zumft, W.G., Gutierrez, A. & Scrutton, N.S.

Biochem. J.,355, 39-43.

[93] Two-iron rubredoxin of Pseudomonas oleovorans: production, stability and characterization of the individual Fe-binding domains by optical, CD and NMR spectroscopies (2001)

Perry, A., Lian, L-Y., Scrutton, N.S.

Biochem. J.354 89-98.

[92] Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains (2001)

Gutierrez, A., Lian, L-Y., Wolf, C.R., Scrutton, N.S. & Roberts, G.C.K.

Biochemistry, 40, 1964-1975, DOI: 10.1021/bi001719m

[91] Importance of barrier shape in enzyme catalysed reactions: vibrationally assisted hydrogen tunneling in TTQ-dependent amine dehydrogenases (2001)

Basran, J., Patel, S., Sutcliffe, M.J. & Scrutton, N.S.

J. Biol. Chem., 276, 6234-6242, DOI: 10.1074/jbc.M008141200 Free Access

[90] Degradation of explosives by nitrate ester reductases (2001)

Williams, R.E., Rathbone, D.A., Moody, P.C.E., Scrutton, N.S. & Bruce, N.C.

Biochem.Soc. Symp. 68, 143-153.

[89] Trp-676 facilitates nicotinamide exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the W676H and W667A mutant reductases (2000)

Gutierrez, A., Doehr, O., Paine, M., Wolf, C.R., Scrutton, N.S. & Roberts, G.C.K.

Biochemistry, 39, 15990-15999, DOI: 10.1021/bi002135n

[88] Enzyme catalysis: over-the-barrier or through-the-barrier? (2000)

Sutcliffe, M.J.& Scrutton, N. S.

Trends Biochem.Sci., 25, 405-408, DOI: 10.1016/S0968-0004(00)01642-X

[87] Differential coupling through Val-344 and Tyr-442 of trimethylamine dehydrogenase in electron transfer reactions with ferricenium ions and electron transferring flavoprotein (2000)

Basran, J., Chohan, K.K., Sutcliffe, M.J., & Scrutton N.S.

Biochemistry, 39, 9188-9200, DOI: 10.1021/bi0006868

[86] X-ray scattering (SAXS) studies of Methylophilus methylotrophus (sp. W3A1) electron transferring flavoprotein: evidence for multiple conformational states and an induced fit mechanism for assembly with trimethylamine dehydrogenase (2000)

Jones, M., Basran, J., Sutcliffe, M.J., Grossman, J.G., & Scrutton, N.S.

J. Biol. Chem., 275, 21349-21354, DOI: 10.1074/jbc.M001564200 Free Access

[85] Structural and biochemical characterization of recombinant wild-type and a C30A mutant of trimethylamine dehydrogenase from Methylophilus methylotrophus (sp.W3A1) (2000)

Trickey, P., Basran, J., Lian L-Y., Chen, Z-W., Barton, J.D., Sutcliffe, M.J., Scrutton, N.S. & Mathews, F.S.

Biochemistry, 39, 7678-7688, DOI: 10.1021/bi9927181

[84] Formation of W3A1 electron-transferring flavoprotein (ETF) hydroquinone in the trimethylamine dehydrogenase/ETF protein complex (2000)

Jang, M-H., Scrutton, N. S. & Hille, R.

J. Biol. Chem. 275, 12546-12552, DOI: 10.1074/jbc.275.17.12546 Free Access

[83] Kinetic studies of the mechanism of C-H bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp 1-IN (2000)

Harris, R. J., Meskys, R., Sutcliffe, M. J. & Scrutton, N. S.

Biochemistry 39, 1189-1198, DOI: 10.1021/bi991941v

[82] Enzymology takes a quantum leap forward (2000)

Sutcliffe, M. J. & Scrutton, N. S.

Phil. Trans. Roy. Soc. Series A. 358, 367-386, DOI: 10.1098/rsta.2000.0536

[81] Trimethylamine dehydrogenase and electron transferring flavoprotein (2000)

Scrutton, N. S. & Sutcliffe, M. J.

"Enzyme Catalysed Electron and Radical Transfer" (Eds. Holzenburg, A. & Scrutton, N. S.), Kluwer Academic Publishers, pp. 145-181, DOI: 10.1007/0-306-46828-X_5