Publications
The Scrutton Group has published over 500 research articles covering a broad range of interdisciplinary topics.
Explore our publications via the following links:
Books, Commentaries, Patents, etc.
Highlights:
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis (2019) S. Zhang, D. J. Heyes, L. Feng, W. Sun, L. O. Johannissen, H. Liu, C. W. Levy, X. Li, J. Yang, X. Yu, M. Lin, S. J. O. Hardman, R. Hoeven, M. Sakuma, S. Hay, D. Leys, Z. Rao, A. Zhou, Q. Cheng & N. S. Scrutton, Nature, DOI: 10.1038/s41586-019-1685-2
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites (2019) S. Zhang, M. Sakuma, G. S. Deora, C. W. Levy, A. Klausing, C. Breda, K. D. Read, C. D. Edlin, B. P. Ross, M. Wright Muelas, P. J. Day, S. O’Hagan, D. B. Kell, R. Schwarcz, D. Leys, D. J. Heyes, F. Giorgini & N. S. Scrutton, Communications Biology, 2, 271, DOI:10.1038/s42003-019-0520-5
An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme (2016) Ortmayer, M., Lafite, P., Menon, B. R. K., Tralau, T., Fisher, K., Denkhaus, L., Scrutton, N. S., Rigby, S. E. J., Munro, A. W., Hay, S., Leys, D., Nature, 539, 593-597, DOI: 10.1038/nature20159
Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades (2015) Mutti, F. G., Knaus, T., Scrutton, N. S., Breuer, M., Turner, N. J., Science, 349, 6255, 1525-1529. DOI: 10.1126/science.aac9283
The photochemical mechanism of a B12-dependent photoreceptor protein (2015) Kutta, R. J., Hardman, S. J. O., Johannissen, L. O., Bellina, B., Messiha, H. L., Ortiz-Guerrero, J. M., Elías-Arnanz, M., Padmanabhan, S., Barran, P., Scrutton, N. S., Jones, A. R., Nature Communications, 6, 7907, DOI: 10.1038/ncomms8907
New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition (2015) Payne, K. A. P., White, M. D., Fisher, K., Khara, B., Bailey, S. S., Parker, D., Rattray, N. J. W., Trivedi, D. K., Goodacre, R., Beveridge, P., Barran, P., Rigby, S. E. J., Scrutton, N. S., Hay, S., and Leys, D., Nature, 522, 497-501, DOI:10.1038/nature14560
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis (2015) White, M. D., Payne, K. A. P., Fisher, K., Marshall, S. A., Parker, D., Rattray, N. J. W., Trivedi, D. K., Goodacre, R., Rigby, S. E. J., Scrutton, N. S., Hay, S., and Leys, D., Nature, 522, 502-506, DOI:10.1038/nature14559
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (2014) Leferink, N., Antonyuk, S. V., Houwman, J. A., Scrutton, N. S., Eady, R. R. & Hasnain, S. S., Nature Comms., 5, 4395, DOI: 10.1038/ncomms5395
Structural basis of kynurenine 3-monooxygenase inhibition (2013) Amaral, M., Levy, C., Heyes, D. J., Lafite, P., Outeiro, T., Giorgini, F., Leys, D. & Scrutton, N. S., Nature, 496, 382-385, DOI: 10.1038/nature12039
Updated structure of Drosophila cryptochrome (2013) Zoltowski, B. D., Vaidya, A. T., Top D., Widom, J., Young, M. W, Crane, B. R., Levy, C., Jones, A. J., Scrutton, N. S. & Leys, D., Nature, 495, E3-4, DOI: 10.1038/nature11995
Good vibrations in enzyme catalysed reactions (2012) Hay, S & Scrutton N. S. Nature Chemistry 4, 161-168, DOI: 10.1038/nchem.1223
Atomic description of an enzyme reaction dominated by proton tunnelling (2006). Masgrau, L., Roujeinikova, A., Johannissen, L. O., Basran, J., Ranaghan, K., Hothi, P., Mulholland, A., Sutcliffe, M. J., Scrutton, N. S. & Leys, D. Science 312, 237-241, DOI: 10.1126/science.1126002
Extensive conformational sampling in a ternary electron transfer complex (2003). Leys, D., Basran, J., Talfournier, F., Sutcliffe,M. J. & Scrutton, N. S. Nature Structural Biology 10, 219-225, DOI:: 10.1038/nsb894
Cooperativity induced by a single mutation at the subunit interface of a dimeric enzyme: glutathione reductase (1992). Scrutton, N. S., Deonarain, M. P., Berry, A. & Perham, R. N. Science 258, 1140-1143, DOI: 10.1126/science.1439821
Redesign of the coenzyme specificity of a dehydrogenase by protein engineering (1990). Scrutton, N. S., Berry, A. & Perham, R. N. Nature 343, 38-43, DOI:10.1038/343038a0