Publications

The Scrutton Group has published over 430 research articles covering a broad range of interdisciplinary topics.

Explore our publications via the following links:

2015-2019 Publications

2010-2014 Publications

2005-2009 Publications

2000-2004 Publications

Pre-2000 Publications

Books, Commentaries, Patents, etc.


Highlights:

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites (2019) S. Zhang, M. Sakuma, G. S. Deora, C. W. Levy, A. Klausing, C. Breda, K. D. Read, C. D. Edlin, B. P. Ross, M. Wright Muelas, P. J. Day, S. O’Hagan, D. B. Kell, R. Schwarcz, D. Leys, D. J. Heyes, F. Giorgini & N. S. Scrutton Communications Biology, 2, 271, DOI:10.1038/s42003-019-0520-5

An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme (2016) Ortmayer, M., Lafite, P., Menon, B. R. K., Tralau, T., Fisher, K., Denkhaus, L., Scrutton, N. S., Rigby, S. E. J., Munro, A. W., Hay, S., Leys, D., Nature, 539, 593-597, DOI: 10.1038/nature20159

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades (2015) Mutti, F. G., Knaus, T., Scrutton, N. S., Breuer, M., Turner, N. J., Science, 349, 6255, 1525-1529. DOI: 10.1126/science.aac9283

The photochemical mechanism of a B12-dependent photoreceptor protein (2015) Kutta, R. J., Hardman, S. J. O., Johannissen, L. O., Bellina, B., Messiha, H. L., Ortiz-Guerrero, J. M., Elías-Arnanz, M., Padmanabhan, S., Barran, P., Scrutton, N. S., Jones, A. R., Nature Communications, 6, 7907, DOI: 10.1038/ncomms8907

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition (2015) Payne, K. A. P., White, M. D., Fisher, K., Khara, B., Bailey, S. S., Parker, D., Rattray, N. J. W., Trivedi, D. K., Goodacre, R., Beveridge, P., Barran, P., Rigby, S. E. J., Scrutton, N. S., Hay, S., and Leys, D., Nature, 522, 497-501, DOI:10.1038/nature14560

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis (2015) White, M. D., Payne, K. A. P., Fisher, K., Marshall, S. A., Parker, D., Rattray, N. J. W., Trivedi, D. K., Goodacre, R., Rigby, S. E. J., Scrutton, N. S., Hay, S., and Leys, D., Nature, 522, 502-506, DOI:10.1038/nature14559

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (2014) Leferink, N., Antonyuk, S. V., Houwman, J. A., Scrutton, N. S., Eady, R. R. & Hasnain, S. S., Nature Comms., 5, 4395, DOI: 10.1038/ncomms5395

Structural basis of kynurenine 3-monooxygenase inhibition (2013) Amaral, M., Levy, C., Heyes, D. J., Lafite, P., Outeiro, T., Giorgini, F., Leys, D. & Scrutton, N. S., Nature, 496, 382-385, DOI: 10.1038/nature12039

Updated structure of Drosophila cryptochrome (2013) Zoltowski, B. D., Vaidya, A. T., Top D., Widom, J., Young, M. W, Crane, B. R., Levy, C., Jones, A. J., Scrutton, N. S. & Leys, D., Nature, 495, E3-4, DOI: 10.1038/nature11995

Good vibrations in enzyme catalysed reactions (2012) Hay, S & Scrutton N. S. Nature Chemistry 4, 161-168, DOI: 10.1038/nchem.1223

Atomic description of an enzyme reaction dominated by proton tunnelling (2006). Masgrau, L., Roujeinikova, A., Johannissen, L. O., Basran, J., Ranaghan, K., Hothi, P., Mulholland, A., Sutcliffe, M. J., Scrutton, N. S. & Leys, D. Science 312, 237-241, DOI: 10.1126/science.1126002

Extensive conformational sampling in a ternary electron transfer complex (2003). Leys, D., Basran, J., Talfournier, F., Sutcliffe,M. J. & Scrutton, N. S. Nature Structural Biology 10, 219-225, DOI:: 10.1038/nsb894

Cooperativity induced by a single mutation at the subunit interface of a dimeric enzyme: glutathione reductase (1992). Scrutton, N. S., Deonarain, M. P., Berry, A. & Perham, R. N. Science 258, 1140-1143, DOI: 10.1126/science.1439821

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering (1990). Scrutton, N. S., Berry, A. & Perham, R. N. Nature 343, 38-43, DOI:10.1038/343038a0